Slime Molds
Dog Vomit?
resulting in fish kills.
Red and Brown Algae
Source of agar!!
Biofilms on rocks (algae and cyanobacteria)
Dental Plaque
What do microorganisms look like?
Macroscopic
Mushrooms
Molds
Algal blooms
Biofilms (slime) on rocks
Plaque
Microscopic
All kinds of shapes
Got a Splinter?
BACTERIA
Coccus (cocci)
Streptococci
Diplococci
Staphylococci
BACTERIA
RODS
Straight
Curved
SPIRALS
Treponema pallidum
Budding yeasts
Unicellular Algae
Protists
How microbiology became a science
The Beginnings of Microbiology
Antoni van Leeuwenhoek Late 1600’s
The Transition Period
Spontaneous generation
The Golden Age of Microbiology
Louis Pasteur
Germ theory of disease
Robert Koch
Other pioneers of Microbiology
The Slow Death of Spontaneous Generation (1668-1859)
Russell Levine and Chris Evers
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From the time of the ancient Romans, through the Middle Ages, and until the late nineteenth century, it was generally accepted that some life forms arose spontaneously from non-living matter. Such "spontaneous generation" appeared to occur primarily in decaying matter. For example, a seventeenth century recipe for the spontaneous production of mice required placing sweaty underwear and husks of wheat in an open-mouthed jar, then waiting for about 21 days, during which time it was alleged that the sweat from the underwear would penetrate the husks of wheat, changing them into mice. Although such a concept may seem laughable today, it is consistent with the other widely held cultural and religious beliefs of the time.
Ancient Chinese medical text – 1766 BC
Romans (1st Century BC)
“Invisible animals” cause disease
Malaria led to fall of Roman Empire
Vector not invisible!
Organism is! Plasmodium falciparum
Hooke 1665
•Cork was composed of cells
Antoni van Leeuwenhoek
A. van Leeuwenhoek’s lens and Drawings
“tooth scrapings”?
Blood cells through Leeuwenhoek’s lens
Leeuwenhoek’s drawings of sperm
How microbiology became a science
The Beginnings of Microbiology
Antoni van Leeuwenhoek Late 1600’s
The Transition Period
Spontaneous generation
The Golden Age of Microbiology
Louis Pasteur
Germ theory of disease
Robert Koch
Other pioneers of Microbiology
Spontaneous Generation
•The hypothesis that living organisms arise from nonliving matter is called spontaneous generation. According to spontaneous generation, a “vital force’ Forms life.
Francesco Redi
Redi (1668) – Maggots do not arise from rotting meat
Use of Controls in scientific experiments
Needham (1745)
•Boiled broth …
•Poured it into a flask and covered
•Soon was teeming with growth
•He claimed this experiment proved spontaneous generation
•Scientific controls? Repeated tests?
Lazzaro Spallanzani
Spallanzani (1765)
•Heated and sealed flasks and observed no growth!
•Spallanzani claimed air microbes contaminated Needham’s broth
•Needham claimed “vital force” was sealed out!
How microbiology became a science
The Beginnings of Microbiology
Antoni van Leeuwenhoek
The Transition Period
Spontaneous generation
The Golden Age of Microbiology 1857-1914
Louis Pasteur
Germ theory of disease
Robert Koch
Other pioneers of Microbiology