History of Microbiology
Plan for today:
Finish up intro stuff and get to the history ofmicrobiology.
 
 
What do microorganisms look like?
 
Macroscopic
Mushrooms
Molds
Algae
Biofilms (slime) on rocks
Dental Plaque
 
Microscopic
All kinds of shapes
 

Slime Molds

Dog Vomit?

Cyanobacterial and
algal blooms …

 

resulting in fish kills.

Red and Brown Algae

Source of agar!!

 

Biofilms on rocks (algae and cyanobacteria)

 

Dental Plaque

 

What do microorganisms look like?

 

Macroscopic

Mushrooms

Molds

Algal blooms

Biofilms (slime) on rocks

Plaque

 

Microscopic

All kinds of shapes

Got a Splinter?

BACTERIA

 

Coccus (cocci)

Streptococci

Diplococci

 

Staphylococci

BACTERIA

RODS

Straight

Curved

SPIRALS

Treponema pallidum

 

Budding yeasts

Unicellular Algae

Protists

How microbiology became a science

The Beginnings of Microbiology

Antoni van Leeuwenhoek Late 1600’s

 

The Transition Period

Spontaneous generation

 

The Golden Age of Microbiology

Louis Pasteur

Germ theory of disease

Robert Koch

Other pioneers of Microbiology

The Slow Death of Spontaneous Generation (1668-1859)

Russell Levine and Chris Evers

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From the time of the ancient Romans, through the Middle Ages, and until the late nineteenth century, it was generally accepted that some life forms arose spontaneously from non-living matter. Such "spontaneous generation" appeared to occur primarily in decaying matter. For example, a seventeenth century recipe for the spontaneous production of mice required placing sweaty underwear and husks of wheat in an open-mouthed jar, then waiting for about 21 days, during which time it was alleged that the sweat from the underwear would penetrate the husks of wheat, changing them into mice. Although such a concept may seem laughable today, it is consistent with the other widely held cultural and religious beliefs of the time.

 

Ancient Chinese medical text – 1766 BC

Romans (1st Century BC)

“Invisible animals” cause disease

Malaria led to fall of Roman Empire

Vector not invisible!

Organism is!  Plasmodium falciparum

 

Hooke 1665

Cork was composed of cells

 

Antoni van Leeuwenhoek

A. van Leeuwenhoek’s lens and Drawings

“tooth scrapings”?

 

Blood cells through Leeuwenhoek’s lens

Leeuwenhoek’s drawings of sperm

How microbiology became a science

The Beginnings of Microbiology

Antoni van Leeuwenhoek Late 1600’s

 

The Transition Period

Spontaneous generation

 

The Golden Age of Microbiology

Louis Pasteur

Germ theory of disease

Robert Koch

Other pioneers of Microbiology

Spontaneous Generation

The hypothesis that living organisms arise from nonliving matter is called spontaneous generation. According to spontaneous generation, a “vital force’ Forms life.

Francesco Redi

Redi (1668) – Maggots do not arise from rotting meat

Use of Controls in scientific experiments

 

Needham (1745)

Boiled broth …

Poured it into a flask and covered

Soon was teeming with growth

He claimed this experiment proved spontaneous generation

Scientific controls?  Repeated tests?

Lazzaro Spallanzani

Spallanzani (1765)

Heated and sealed flasks and observed no growth!

Spallanzani claimed air microbes contaminated Needham’s broth

 

Needham claimed “vital force” was sealed out!  

 

How microbiology became a science

The Beginnings of Microbiology

Antoni van Leeuwenhoek

 

The Transition Period

Spontaneous generation

 

The Golden Age of Microbiology 1857-1914

Louis Pasteur

Germ theory of disease

Robert Koch

Other pioneers of Microbiology