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BIOLOGY 635 - TOXICOLOGY Dr. Fred McCorkle Office Hours: Mon: 11-1:50 Brooks Hall 114 Tus: 1-1:50 774-3348 or by appt. Toxicology is the study of toxic chemicals, their effects on living organisms, and the fate of the chemical in the organism. Prerequisites: CHM 345, 346, 521, 522,Bio 392 or permission of instructor. Text: No appropriate text curently available. Course Objectives: 1. Understanding how toxic compounds act on various organisms. 2. Examine how living organisms handle or metabolize these toxic compounds. 3. Fate of the chemical in the organism. Course Outline:Tentative Lecture Schedule Lectures on the Following Topics Aug 30 Introduction Receptor Theory of Toxic Action Sept 6 Biological Assay Insecticides: Botanical 13 Organochlorine Compounds Organophosphorus Compounds 20 Carbamate Miscellaneous Compounds 27 Insecticides and the Environment Herbicides: Auxin Mimics Oct 4 Inhibitors of Photosynthesis Miscellaneous Compounds 11 Fungicides Interference with Energy Metabkolism 18 Interference with Nerve Impluse Transmission Interference with Development, Reproduction, and Behavior 25 Metabolism of Foreign Ckompoounds Synergism and Antagonism Nov 1 Resistance Hematotoxicity: Toxic effects in the Blood 8 Nephrotoxicity: Toxic effects in the Kidneys Dermatotoxicity: Toxic effects in the Skin 15 Pulmonotoxicity: Toxic effects in the Lung Hepatotoxicity: Toxic effects in the Liver 29 The Toxic effects of Metals Mutagensis Dec 6 Carcinogenesis Reproductive Toxicology Oral Reports 13 Final Exam 6 - 9:00 pm ( Oral Reports ) Evaluation: Grading
2 - Take Home Exams - 40 % ( 20% Each) Final Comprehensive Exam (take Home) _ 40 % Oral Report ( on toxic Chemical ) - 10 % Term Paper - 10 % Each student will give a 5-10 minute oral report on a toxic compound. This should include LD50, the active site, symptoms of poisoning, treatment if any and chemical structure. The term paper will be a synopsis dealing with a specific area of Toxicology based upon information from at least 7 original research articles from current scientific journals. A photocopy of the first page of each article will be included with the paper. This paper should be no less than 5 typed pages, not counting title page, or reference page. Papers turned in late will automatically receive a 10 % reduction in grade per day late. Term papers are due November 1, 2000.
CMU provides students with disabilities reasonable accommodation to participate in educational programs, activities or services. Students with disabilities requiring accommodation to participate in class activities or meet course requirements should first register with the office of Student Disability Services (250 Foust Hall, telephone #517-774-3018, TDD #2568), and then contact me as soon as possible. . |