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BIOLOGY 324 - CELL BIOLOGY Fall, 2001 DR. Fred McCorkle OFFICE HOURS: Brooks 114 M 1-3 PM & 774-3348 W 1-3 PM or by Appt.
CLASS MEETING TIMES : 9:00 - 9:50 AM MWF
REQUIREMENTS 1. Textbook: The World of the Cell, Third Edition, W. Becker, J. Reece, and M. Poenie, 1996. Benjamin/Cummings Publishing Company
GRADING Students will be evaluated according to the following: 1.Essay Examinations and short answer(4) .....(20% each)........................80% 2. Library Paper (1)...................................20% This paper will be a synopsis dealing with a specific area of cell biology based upon information from atleast five original research articles from current scientific journals. A photo-copy of the first page of each article should be included with the paper. This paper should be no longer than 10 typed pages and is due on or before November 14, 2001. Papers turned in late (up to three days) will automatically receive a 5 points reduction grade per day. Those over three days late will not be accepted. See below.
Date Lecture Topic Tentative Reading Assignment Aug 27 Introduction: Cell Biology The Composite Cell Chapter 1 29 Cell Structure Chapter 4 31 Cell Function Chapter 4 Sept 5 Cellular Chemistry Chapter 3 7 Cellular Macromolecules: Proteins Chapter 3 10 Cellular Macromolecules: Proteins Chapter 3 12 Cellular Macromolecules: Polysaccharides Chapter 3 14 Cellular Macromolecules: Polysaccharides Chapter 3 17 Cellular Macromolecules: Lipids Chapter 3 19 Cellular Macromolecules: Nucleic Acids Chapter 3 21 Exam
24 Bioenergetics Chapter 5
26 Enzymes Chapter 6 Oct 1 Enzymes Chapter 6
3 Cell Metabolism: Carbohydrate Chapter 11 5 Cell Metabolism: Catabolism Chapter 11 8 Cell Metabolism: Lipid Chapter 11 10 Metabolic Regulation Chapter 12 12 Metabolic Regulation Chapter 12 15 Metabolic Regulation Chapter 12 17 Metabolic Regulation Chapter 12 19 EXAM 22 Fractionation of Tissues and Cells 24 Plasma Membrane Chapter 7 26 Plasma Membrane Chapter 7 29 Transport Across Membrane Chapter 8 31 Transport Across Membrane Chapter 8 Nov 2 Endoplasmic Reticulum Chapter 9 5 Mitochondria Chapter 12 7 Cell Junctions Chapter 10 9 Chloroplast Chapter 13 12 EXAM 14 The Golgi Apparatus or Complex Chapter 9 16 Lysosomes and Microbodies Chapter 9 19 DNA and Nucleus Chapter 14 21 Cell Cycle Chapter 15 22 Thanksgiving Holiday 26 Meiosis & Genetic Variability Chapter 24
28 Ribosomes & Synthesis of Proteins Chapter 16 & 18 30 Cytoskeletal Chapter 20
Dec 3 Muscle Cells and Nerve Cells Chapter 21 & 22 5 Messengers and Receptors Chapter 23 7 Immunity & Cancer Chapter 24 & 25 12 Final Exam 8:00 - 9:50 AM (Wednesday)
EXPECTATIONS: This is a 300-level course and it will be taught at a rigorous level. Students are expected to have taken BIO 101 or equivalent, BIO 203, BIO 208, and BIO 218 as well as Introductory Chemistry Organic Chemistry is strongly recommended. Students are expected to spend at least 2 hours per lecture period in preparation and study. Since this is a biology course, a major goal is to encourage you to "think biologically," with understanding rather than dependence on rote memorization.
MISCELLANEOUS: Being in class both hours is very important. Students with 5 hours of unexcused absences will have their course grade dropped by one letter grade per additional unexcused absence. Students with extended absences due to illness or other excused reason should contact me about making up required course work. CMU provides students with disabilities reasonable accommodation to participate in educational programs, activities or services. Students with disabilities requiring accommodation to participate in class activities or meet course requirements should first register with the office of Student Disability Services (250 Foust Hall, telephone #517-774-3018, TDD #2568), and then contact me as soon as possible.
Library Paper for Cell Biology
The purpose of this assignment is to introduce you to the primary literature of cell biology and to encourage critical thinking skills. The library paper is due Nov. 14, 2001.
The library paper will be on a topic of your own choosing but must be on a Cell Biology topic.. T Write a 5-6 page library paper using at least 5 original research articles (12-pt. double-spaced, 1" margins) including a short introduction. Review articles may be used as these synthesis the experiments of others rather than describing original experiments but these review articles will not count as original research articles. Thus, there are no methods and materials or results sections in review articles. Research articles describe original experiments that the authors have done, and usually follow the standard format of Introduction, Materials and Methods, Results, Discussion, References. The exceptions are research articles published in Science or Nature magazines; in these journals, to save space the methods are briefly described in either the figure legends or in footnotes, and the article is not broken up by section subheadings. The main body will address the research of the these papers on your topic. Use V. E. McMillan ‘s Writing Papers in the Biological Sciences as a source for technique and style..
Title format: Title.
Introduction: Do not use heading, do restrict to one or two paragraphs. The textbook should not be referenced. Remember to reference all this work as it is not your work. This is true for this whole paper.
Body: Do not use heading, but start a new paragraph with an introductory sentence such as, "In the study by Frye and Edidin (1970), ..." Explain any unusual techniques used; if you don't understand the methods, do some research to find out about them. Address the hypothesis of the experimenters, the specific experiments to test the hypothesis, and the conclusions drawn. What controls were done? Were you convinced by the results? How strong was their experimental evidence? Did the authors over-interpret their data in the Discussion section?
References: Use a heading for this section only. Alphabetize by first author. Provide complete author list, date, title, journal, volume, and pages.
Citation style: Use (Hertzler, 1998) for one author, (Hertzler and McCorkle, 1998) for two authors, and (Hertzler et al., 1998) for multiple authors within the text. Use (reviewed by Hertzler, 1998) to reference your review in the first paragraph. Use a citation after the first sentence of your research paper discussion, and again whenever a major finding or conclusion is made. Do not cite page numbers. Papers with missing citations will receive a Zero.
Spelling and Grammar: Use but don't rely on the spell-checker on your computer. Always proofread. Points will be lost for sloppy proof reading.
Plagiarism: Do not use quotation marks to cite passages. Put things in your own words. You may think the authors expressed their sentence in the best possible way, but you must rephrase it, and correctly attribute it. I will check the reference if in doubt, and plagiarized papers will receive a Zero with the possibility of further action through the Office of Student Life. If you are unsure of what constitutes plagiarism, consult the handbook PLAGIARISM: A BRIEF OVERVIEW.
Library Use of articles: You must either use references in the library or make a photocopy. Ripping out research articles from journals in the library is a scholarly crime as well as theft and destruction of state property, and will be addressed accordingly.
Library Paper Grading: The paper will be worth 100 points. Papers received late will receive a 5 point per day reduction, starting after the class period on the day due and will not be accepted after three days. Do not use personal pronouns in your paper ( they, I , He or She). You will lost one point each time you use these.
This paper can not have been used in any other course at CMU or other college or university.
Classroom Civility : Each CMU student is encouraged to help create an environment during class that promotes learning, dignity, and mutual respect for everyone. Students who speak at inappropriate times, sleep in class, display inattention, take frequent breaks, interrupt the class by coming to class late, engage in loud or distracting behaviors, use cell phones or pagers in class, use inappropriate language, are verbally abusive, display defiance or disrespect to others, or behave aggressively toward others could be asked to leave the class and subjected to disciplinary action under the Code of Student Rights, Responsibilities and Disciplinary Procedures.
Policy on Academic Integrity: In may 2001, the Central Michigan University Academic Senate approved the Policy on Academic Integrity which applies to all university students. Copies are available on the CMU website at and in the Academic Senate Office in room 108 of Bovee University Center. All academic work is expected to be in compliance with this policy.
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