Fred Miller McCorkle, Ph.D.
Professor of Biology
Graduate Coordinator and Pre Med Advisor and Coordinator
Office - Brooks 114
Office Phone - 989-774-3348
Office Hours : FOR Spring, 2003 Monday 1:00 pm - 2:50 pm
Tuesday 1:00 pm - 2:50 pm
by Appt.
E-Mail Address : Fred.McCorkle@cmich.edu
Professional Training
Ph. D. Mississippi State University, 1978 Animal Physiology & Immunology
Minor: Biochemistry
M. S. Mississippi State University, 1972 Animal Physiology
Minor: Biochemistry
B. S. Delta State University, 1966 Biology Major and Chemistry & History Minors
Course To Be Taught Summer, 2003
Bio 324 Cell Biology
Courses To BeTaught Fall, 2003
Bio 537 Immunology
Bio 610 Hormones
Courses for Spring, 2003
Bio 576 Animal Cell Culture
Bio 577 Hematology
Bio 630 Art of Scientific Communications
Courses Taught Fall, 2001
Bio 537 Immunology
Bio 324 Cell Biology
Bio 630 Art of Scientific Communications
Research Interests - Immunology
Specifically - Avian Immunology
Immunotoxicology
Chemicals Used in Immunotoxicity Studies with the Avian Macrophage
Hormones Studied:
Testosterone
Serotonin
Dopamine
Epinephrine
Norepinephrine
Beta - Endorphin
Melatonin
Pesticides
Diquat
Combburst Polymers
Vitamin E
Avian Macrophages - Techniques Used in Immunotoxicity Studies
Tissue Culture
Cytotoxicity
Phagocytosis
Sheep Red Blood Cells
E. coli
Nitric oxide synthase
Professional Society Memberships
American Association of Immunologists
American Association of Avian Pathologists
American Killifish Association
American Society of Zoologists
International Society for Development and Comparative Immunology
Poultry Science Association
Sigma Xi
Current Graduate Students Working with Me
Plan A ( Thesis ) and Plan B ( Non-thesis )
Carol L Injasoulian - writing her thesis (almost finished and to her committee)
Randy J. McGuirk - writing his thesis
Barbara A. Guile - Plan B
Michael R. Darabos - Plan B
Stephanie M. Brandal - Plan A
Matthew J. Weiland - Plan A
Shannon M. Krieger - Plan A
Recent Graduate Student
Christine C. Brillhart - Plan B Spring, 1994
Dawn E. Seeburger - Plan B Spring, 1994
Tammy Lynn Card - Plan B Spring, 1994
Phyllis N. Bonamino - Plan B Spring, 1994
Todd Festerling - Plan B Fall, 1994
Rebecca L. Uzarski - Plan A Summer, 1995
Carrie A. Roth - Plan A Summer, 1995
Yehong (Jamie) Wang - Plan A Summer, 1995
Jennifer A. Florian - Plan A Summer, 1995
Todd A. Felix - Plan A Fall, 1995
Karen A Humbyrd - Plan A Spring, 1996
Pamela J. Spencer - Plan A Summer, 1996
Andrew B. Scott - Plan A Spring, 1997
Scott A. Greig - Plan A Spring, 1997
Pauline Piotrowski Whitman- Plan B Fall, 1998
Tricia M. DeWyse - Plan A Spring, 1999
Matthew Hayen- Plan B Fall, 1999
Karin Perry - Plan B Spring, 2000
Amy Lynn Brumm - Plan B Spring, 2000
Connie Marie Wiescinski - Plan A Spring, 2000
Roberta J. White - Plan B Fall, 2000
Nancy Clough - Plan B Fall, 2000
Jennifer Paquette - Plan A Spring, 2001
Robert P. Lipinski - Plan B Spring, 2001
Tricia L. Anscomb - Plan A Summer, 2001
Carrie M. Bernard - Plan B Summer, 2001
Daniel R. Zanotii - Plan B Spring, 2002
Personal Interests
Breeding Tropical Fish Primarily Killifish
I have 75 aquariums that house about 30 species of tropical fish. I am breeding most of these.
Member of Michigan Killifish Association and the American Killifish Association
I have just finished (Jan., 2000) the Master Killifish Breeder Award Program sponsored by the Michigan Killifish Association making me a Master Killifish Breeder. This was a 5 year journey to complete and lead me from 4 aquariums to the 124 tanks back to 75 tanks today.
Duck Hunting and Labs
Publications
1972. McCorkle, F.M. Master's Thesis: Studies of Mirex Toxicity, It's Residue Levels, and Effects on Succinic Dehydrogenase Activity in Gambusia affinis and Lepomis cyanellus. Mississippi State University.
1978. Mccorkle, F.M. Ph.D. Dissertation: The Effects of Aging on Immune Competence in the Chicken. Mississippi State University.
1974. McCorkle, F.M. and J.D. Yarbrough. The in vitro effects of mirex of succinic dehydrogenase activity in Gambusia affinis and Lepomis cyanellus. Bull. Environ. Contamin. Toxicol. 11:364.
1975. Chambers, J.E., F.M. McCorkle, J.W. Carroll, J.R. Heitz, L. Lewis and J.D. Yarbrough. Variation in enzyme activities of the American oyster (Crassostaea virginica) relative to size and season. Comp. Biochem. Physiol. 51B:145.
1977. McCorkle, F.M., J.E. Chambers and J.D. Yarbrough. Acute toxicities of selected herbicides to fingerling channel catfish, Ictalurus punctatus. Bull. Environ. Contamin. Toxicol. 18:287.
1978. Stinson, R.S., F.M. McCorkle and B. Glick. Nylon wool column separation of chicken thymic-derived (T) and bursal-derived (B) lymphocytes. Poultry Sci. 52(2):518-522.
1978. Chambers, J.E., J.R. Heitz, F.M. McCorkle and J.D. Yarbrough. The effects of crude oil on enzymes in the brown shrimp (Penaeus sp.). Comp. biochem. Physiol. 61C:29-32.
1979. McCorkle, F.M., J.E. Chambers and J.D. Yarbrough. Seasonal effects on selected tissue enzymes in channel catfish, Ictalurus punctatus. Comp. Biochem. Physiol. 62B:151-153.
1979. Olah, I., B. Glick, F. McCorkle and R. Stinson. Light and electron microscope structure of secretory cells in the medulla of bursal follicles of normal and cyclophosphamide treated chickens. Dev. Comp. Immunol. 3:101-115.
1979. Chambers, J.E., J.R. Heitz, F.M. McCorkle and J. D. Yarbrough. Enzyme activities following chronic exposure to crude oil in a simulated ecosystem. I. American oysters and brown shrimp. Environ. Res. 20:133-139.
1979. Chambers, J.E., J.R. Heitz, F.M. McCorkle and J.D. Yarbrough. Enzyme activities following chronic exposure to crude oil in a simulated ecosystem. II. Striped mullet. Environ. Res. 20:140-147.
1979. McCorkle, F.M., J.E. Chambers and J.D. Yarbrough. Tissue enzyme activities following exposure to dietary mirex in the channel catfish, Ictalurus punctatus. Environ. Pollution 19:195-199.
1979. McCorkle, F.M., R. Stinson and B. Glick. Abiphasic response in the graft-vs-host response in aging chickens. Cell. Immunol. 46:208-212.
1979. McCorkle, F.M., R. Stinson, I. Olah and B. Glick. The chickens femoral-lymph nodules: T and B cells and immune response. J. Immunol. 123:667-669.
1979. McCorkle, F.M., J.E. Chambers and J.D. Yarbrough. Tolerance of low oxygen stress in insecticide- resistant and susceptible populations of mosquitofish (Gambusia affinis). Life Sci. 25:1513-1518.
1980. Stinson, R.S., F.M. McCorkle, M.M. Mashaly and B. Glick. The effect of diurnal rhythms on immune functions in New Hampshire chickens. Int. Arch. Allergy Appl. Immunol. 61:220-226.
1980. McCorkle, F.M., I. Olah and B. Glick. The historical response of phtohemagglutinin (PHA) injection in the wattle of the chicken. Poultry Sci. 59:616-623.
1980. McCorkle, F.M., R. Taylor, R. Stinson, E.J. Day and B. Glick. The effects of a megalevel of vitamin C on the immune response of the chicken. Poultry Sci. 59:1324-1327.
1980. McCorkle, F.M., and B. Glick. The effect of aging on the immune competence in the chicken: Antibody-mediated immunity. Poultry Sci. 59:669-672.
1980. Olah, I., F.M. McCorkle and B. Glick. Lectin-induced giant cell formation in the chicken wattle. Poultry Sci. 59:616-623.
1982. Christensen, V.L. and F.M. McCorkle. Character-ization of incubational egg weight losses during a reproductive cycle of three types of turkeys. Poultry Sci. 61:848-85.
1982. Christensen, V.L. and F. M. McCorkle. Turkey egg weight losses during incubation and embryonic mortality. Poultry Sci. 61:1209-1213.
1982. McCorkle, F.M., G.H. Luginbuhl and D.G. Simmons. Effects of Alcaligenes faecalis on delayed hypersensitivity in neonatal turkeys. Avain Diseases 26:782-786.
1983. McCorkle, F.M., G.H. Luginbuhl, D.G. Simmons, G.W.Morgan and J.P. Thaxton. Ontogeny of delayed hypersensitivity in neonatal turkey. Develop. Comp. Immunol. 7:517-524.
1983. McCorkle, F.M. and G.A. Leslie. IgM-plaque-forming cells in the peripheral blood of chickens. Develop. Comp. Immunol. 7:391-396.
1983. McCorkle, F.M., D.G. Simmons and G.H. Luginbuhl. Graft vs host response in Alcaligenes faecalis-infected turkey poults. Am. J. Vet. Res. 44:6183.
1983. Simmons, D.G., L.P. Rose, F.M. McCorkle and G.H. Luginbuhl. Histamine sensitizing factor of Alcaligenes faecalis. Avian Diseases 27:171-177.
1983. McCorkle, F.M., V.L. Christensen and J.P. Thaxton. Antisperm antibodies and fertility of turkey hens. J. Reprod. Immunol. 5:363-370.
1983. Berkhoff, H.A., F.M. McCorkle and T.S. Brown. Pathogenicity of various strains of Alcaligenes faeclis for broilers. Avian Dis. 27:707-713.
1984. McCorkle, F.M. and D.G. Simmons Immediate hypersensitivity (Anaphylaxis) response in noninfected and Alcaligenes faecalis infected turkey poults. Avian Diseases 28:579-585.
1984. Edens, F.W., F.M. McCorkle, and D.G. Simmons. Body temperature response of turkey poults infected with Alcaligenes faecalis. Avian Pathology 13:787-795.
1984. McCorkle, F.M. and D.G. Simmons. In Vitro cellular migration of leukocytes from turkey poults infected with Alcaligenes faecalis. Avian Diseases 28:853-857.
1985. McCorkle, F.M., F.W. Edens and D.G. Simmons. Alcaligenes faecalis-infection in turkeys: Effects on serum corticosterone and serum chemistry. Avian Diseases 29:80-89.
1985. McCorkle, F.M., F.W. Edens, and D.G. Simmons. Alcaligenes faecalis - infection and serum chemistry. Avian Diseases 29:80-89
1987. Edens, F.W., F.M. McCorkle, D.G. Simmons and A.G.Yersin. Brain monoamine concentrations in turkey poults with Bordetella avium infection. Avian Diseases, 29:80-89.
1987. Lukacs, N.W., F.W. McCorkle and R.L. Taylor. Monoamines suppress the phytohemagglutinin wattle response in chickens. Develop. and Comp. Immunol. 11:759-768.
1987. Edens, F.W., F.M. McCorkle, D.G. Simmons and A.G.Yersin. Bordetella avium affects on lymphoid tissue monoamine concentrations in turkey poults. Avian Diseases 31:746-751.
1988. McCorkle, F.M. and J.P. Thaxton. Ontogeny of antibody response to Brucella abortus in turkeys. Develop. and Comp. Immunol. 12(3):621-627.
1990. McCorkle, F.M., R.L. Taylor, K.M. Denno and J.M. Jabe. Momnoamines alter in vitro migration of chicken leukocytes. Develop. and Comp. Immunol. 14:85-93.
1990. McCorkle, F.M., and R.L. Taylor. Continuous administration of 5-Hydroxytryptamine alters cellular immunity in chickens. Comp. Biochem. and Physiol. 94C(2):511-514.
1991. Gray, R.S., F.M. McCorkle and R.L. Taylor.Modulation of chicken Plaque-forming Cells by Serotonin and Dopamine. Poultry Science 70:1521-1526.
1993. McCorkle, F. M., and R. L. Taylor. Biogenic Amines Regulate Avian Immunity. Poultry Science 72: 1285-1288.
1994. Ali, R. A., M. A. Qureshi, and F. M. McCorkle. Profile of Chicken Macrophage Function After Exposure to Catecholamines in vitro. Vet.Immunol.Immunopath. 16:611-625.
1994. Denno, K. M., F. M. McCorkle and R. L. Taylor. Catecholamines Modulate Chicken IgM and IgG Plaque-forming Cells. Poultry Science 73:1858-1866.
1994. McCorkle, F. M. and R. L. Taylor. Continuous Administration of Dopamine Alters Cellular Immunity in Chickens. Comp. Biochem. Physiol. 109C:289-293.
1998. McCorkle, F. M. Symposium: Nonlymphoid Cells and their Factors in Immune Response Introduction to the Symposium Poultry Science 77:963.
Papers Presented (Oral Presentations and Posters)
1976. McCorkle, F.M. and J.D. Yarbrough. Formalin toxicity to insecticide-resistant and susceptible mosquitofish (Gambusia affinis). Association of Southern Biologists.
1977. McCorkle, F.M., R.Stinson and B. Glick. Nylon Wool column separation of chicken thymic-derived (T) and bursal-derived (B) lymphocytes. Miss. Acad. Sci.
1977. McCorkle, F.M., R. Stinson, M. Mashaly and B. Glick. The effect of aging on immune competence in the chicken. Poultry Sci. Assoc.
1978. McCorkle, F.M. and B. Glick. The effect of aging on immune competence in the chicken: Cell-mediated immunity. Southern Poultry Science Association.
1978. McCorkle, F.M., R.L. Haynes, M.M. Mashaly, R.S. Stinson and B. Glick. Physiological effects of lesions in the ventral hypothalamus in the chicken. Miss. Acad. Sci.
1978. McCorkle, F.M., I. Olah, and B. Glick. The histological response to phytohaemagglutinin (PHA) injection in the wattle of the chicken. Association of Southern Biologists.
1978. McCorkle, F.M., R.S. Stinson and B. Glick. The effect of aging on immune competence in the chicken: Humoral immunity. Poultry Sci. Assoc.
1978. McCorkle, F.M., R.S. Stinson, I. Olah and B. Glick. Role of the avian lymph node in immunity. Poultry Sci. Assoc.
1979. McCorkle, F., R. Taylor, D. Martin, R. Stinson, E. Taylor and B. glick. Effects of MSMA and DSMA on the immune response in chicks. Poultry Sci. Assoc.
1979. McCorkle, F., B. Glick, and I. Olah. Lectin- induces giant cell formation in the chicken wattle. American Society of Zoologists.
1979. McCorkle, F.M. and G.A. Leslie. Plaque-forming cells in the peripheral blood of chickens. American Society of Zoologists.
1980. McCorkle, F.M., R. Taylor, D. Martin and B. Glick.The effect of perethrin on the immune response of chickens. Southern Poultry Science Assoc.
1980. McCorkle, F.M., G.W. Morgan and J.P. Thaxton. Kinetics of antibody responses in young turkeys. Poultry Sci. Assoc.
1981. McCorkle, F.M., V.L. Christensen and J.P. Thaxton. Relationship between antisperm antibodies and fertility of turkey hens. Poultry Sci. Assoc., British Columbia.
1981. McCorkle, F.M., G.H. Luginbuhl, D.G. Simmons, G.W. Morgan and J.P. Thaxton. Delayed hypersensitivity in neonatal turkeys. Southeastern Immunology Conference, Atlanta, GA.
1981. McCorkle, F.M., G.H. Luginbuhl and D.G. Simmons. Effects of Alcaligenes faecalis on selected components of cell-mediated immunity in turkeys. Conference of Research Workers in Animal Diseases, Chicago, IL.
1981. McCorkle, F.M., G.H. Luginbuhl and D.G. Simmons. Effects of Alcaligenes faecalis on cutaneous basophil hypersensitivity in neonatal turkeys. Conference of Research Workers in Animal Diseases, Chicago, IL.
1981. McCorkle, F.M. and J.P. Thaxton. Ontogeny of antibody production in neonatal turkeys. American Society of Zoologists. Tampa, FL.
1982. McCorkle, F.M., F.W. Edens and D.G. Simmons. Adrenal cortical secretory involvement in Alcaligenes faecalis infection in turkey poults. Southern Poultry Science Society. Atlanta, GA.
1982. McCorkle, F.M., F.W. Edens and D.G. Simmons. Alcaligenes faecalis-infection in turkeys: Effects on serum chemistry, serum corticosterone and body temperature. Conference of Research Workers in Animal Diseases, Chicago,IL.
1982. McCorkle, F.M., and D.G. Simmons. Immediate hypersensitivity in turkey poults and effects of Alcaligenes faecalis-infection. Conference of Research Workers in Animal Diseases. Chicago, IL
1983. McCorkle, F.M., H.A. Berkhoff and D.G. Simmons. Tracheal immunoglobulin response in Alcaligenes faecalis-infected chickens. Southern Poultry Science Society, Atlanta, GA.
1984. McCorkle, F.M., F.W. Edens and D.G. Simmons. Alcaligenes faecalis infection alters tissue monoamines in turkey poults. Conference of Research Workers in Animal Diseases, Chicago, IL.
1985. McCorkle, F.M., D.G. Simmons, L. Rose, and F.W. Edens. Phagocytosis of Alcaligenes faecalis by circulating blood cells of turkey poults. Poultry Science Association, Ames, Iowa.
1985. McCorkle, F.M., F.W. Edens, L. rose, and D.G. Simmons. Bordetella avium in turkeys: Effect on plaque-forming cells. Conference of Research Workers in Animal Diseases, Chicago, IL.
1986. McCorkle, F.M., R.S. Gray, N. Lukcas and R.L. Taylor. Effect of dopamine on plaque-forming cells and delayed hypersensitivity in chickens. Sixth International Congress of Immunology, Toronto, Canada.
1986. McCorkle, F.M., N. Lukcas and R.L. Taylor. Effect of serotonin on delayed hypersensitivity in chickens. Poultry Science Association, Raleigh, N.C.
1988. Mccorkle, F.M. Biogenic amines alter in vitro migration of turkey leukocytes. 39th North Central Avian Disease Conference, St. Paul, Minnesota.
1988. McCorkle, F.M. Biogenic amines alter in vitro migration of chicken leukocytes. Poultry Science Association Annual Meeting, Baton Rouge, Louisiana.
1989. McCorkle, F.M. and R.L. Taylor. Countinuous administration of 5-Hydroxyltryptamine alters cellular immunity in chickens. Poultry Science Association Annual Meeting, Madison Wisconsin.
1990. McCorkle, F.M. and R.L. Taylor. Countinuous administration of dopamine alters cellular immunity in chickens. Poultry Science Association Annual Meeting, Blacksburg, Virginia.
1992. McCorkle, F.M. and R.L. Taylor. Biogenetic Amines regulate Avian Immunity. Poultry Science Association Annual Meeting, University of Arkansas.
1993. McCorkle, F.M., V. Christensen and M.A. Qureshi. Effects of Biogenic Amines on Leukocyte Migration in Turkey Poults. Poultry Science Association Annual Meeting, Michigan State University.
1994. McCorkle, F.M., D. May and R.L. Taylor. Effects of Thyroid Hormones on Avian T Cell Blastogenesis. Poultry Science Association Annual Meeting, Mississippi State University.
1995. McCorkle, F.M., J.A. Florian, J.Y. Wang, R.L. Uzarski, C.A. Roth and R.L. Taylor. Effects of Continuous Administration of Seratonin and Dopamine on Immunity in Chickens. Poultry Science Association Annual Meeting, University of Alberta, Edmonton, Canada.
1996. McCorkle, F.M. Symposium: Non-Lymphoid Cells and Their Factors in Immune Responses. Poultry Science Association Annual Meeting, Louisville, Kentucky.
1997. McCorkle, F.M. The Fish Immune System. MKA Swap Day, Detroit,MI.
1997. McCorkle, F.M. Killifish and Healthy Fish. Anderson Killifish Association, Anderson, IN.
1997. McCorkle, F.M., A.B.Scott, and S.J. McKenna. The Effects of Melatonin on Avian Macrophage Function. Poultry Science Association Annual Meeting, University of Georgia, Athens,Georgia.
1998. McCorkle, F.M. Keeping and Breeding Lameye Killies. Michigan Killifish Association Swap Day.
1998. McCorkle, F.M., and A.B. Scott. The Effects of Substance P on Avian Macrophage Function. Poultry Science Association Annual Meeting, Penn State University, State College,Penn.
1999. McCorkle, F.M. Avian Macrophages and Immunotoxicology. Michigan State University, Comparative Immunology Seminar Series, Fall, Oct. 27.
2001. McCorkle, F. M., and J. Paquette. The effects of homocysteine on th avian macrophage. Poultry Science Association Annual Meeting, Indianapolis, Indiana. July 24-28, 2001.
2001. Paquette, J., and F. M. McCorkle. The effects of epigallocatechin gallate on the avian macrophage. Poultry Science Association Annual Meeting, Indianapolis, Indiana. July 24-28, 2001.
2001. Anascomb,T., and F. M. McCorkle. The in vitro effects of caffic acid phenethyl ester, the active component fo bee propolis, on the avian macrophage. Poultry Science Association Annual Meeting, Indianapolis, Indiana. July 24-28, 2001.
