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Anja
Mueller (Assistant Professor)
PhD,
Washington
University
,
St. Louis
,
1998.
Diplom (Masters), Biology,
University of Regensburg
,
Germany
, 1993
Office:
Dow 374
Phone:
(989) 774 - 3956
Fax:
(989) 774 - 3883
E-mail:
muell1a@cmich.edu
Teaching Emphasis:
Areas:
Organic Chemistry, Polymer Chemistry, Biochemistry
Courses: CHM 345
Organic Chemistry I
CHM 349 Introduction to
Organic Chemistry Laboratory
CHM 561 Polymer Chemistry
Research Program and
Goals:
Biomaterials
Synthesis.
Biomaterials are
materials that can be used in the body for medical applications.
We are interested in hydrophilic polymers, specifically polysaccharides,
because of their non-adhesive properties.
The polymers are synthesized via enzymatic polymerization without toxic
solvents or chemicals.
Artificial Skin
Scaffold.
Polysaccharide-based
materials will be used for the development of an improved, artificial,
biodegradable skin scaffold for burn victims. The
scaffold will be designed with the correct surface structure to allow for cell
differentiation. It will also
incorporate the delivery of various growth factors for improved healing.
The testing will take place in collaboration with a colleague in Biology.
Anti-Thrombogenic
Coating of Artificial Heart Valves.
Patients with
artificial heart valves currently have to take blood-thinning medication for the
rest of their lives, which can carry severe side-effects.
We are developing an anti-thrombogenic coating for artificial heart
valves. With that, no medication
would be needed. This coating will
be enzymatically synthesized under non-toxic conditions and various copolymers
and polymer structures will be tested.
Imprinted
Polymers in Wastewater Treatment.
Each
factory and facility faces various impurities in their wastewater, which might
change over time. The method of
imprinting polymerization will be used to develop a flexible method to easily
manufacture flocculants for specific compounds.
Selected Publications:
-
Omrane K., Bryant E., Mueller A. “Synthesis of a Low Thrombogenic Heart
Valve Coating with Horseradish Peroxidase”, Polymers
for Advanced Technologies 2005, 16,
1-6.
-
Mueller, A., “Enzyme Electrodes for Medical Sensors”, Mini-Reviews
in Medicinal Chemistry, 2005, 5,
231-239.
-
Gan, D., Mueller, A., Wooley, K. L. "Amphiphilic and Hydrophobic
Surface Patterns Generated from Hyperbranched Fluoropolymer(HBFP)–Linear
Polymer Networks: Minimally-adhesive coatings via
crosslinking of hyperbranched fluoropolymers", J. Polym. Sci., Part A:
Polym. Chem., 2003, 41(22), 3531-40.
-
Mueller, A., O'Brien, D. F. "Polymerization of Mesophases of
Hydrated Amphiphiles", Chemical Reviews 2002, 102,
727-757.
-
Bondurant, B., Mueller, A., O'Brien, D. F. "Photoinitiated
Destabilization of Sterically Stabilized Liposomes", Biochim.
Biophys. Acta 2001, 1511 (1), 113-122.
-
Mueller, A., Bondurant, B., O'Brien, D. F. "Light-Stimulated
Destabilization of PEG-Liposomes", Macromolecules
2000, 33 (13), 4799-4804.
-
Keene, R. G.; Mueller, A.; Landick, R.; London, L. “Transcriptional
Pause, Arrest, and Termination Sites of RNA Polymerase II in Mammalian N- and c-myc
Genes”, Nucl. Acids Res. 1999,
27, 3173-3182.
-
Gooden, J.; Gross, M. L.; Mueller, A.; Stefanescu, A.; Wooley, K. L.
“Cyclization in Hyperbranched Polymer Syntheses: Characterization by MALDI-TOF
Mass Spectrometry”, J. Am. Chem. Soc.
1998, 120, 10180-10186.
-
Mueller, A.; Kowalewski, T.; Wooley, K. L. “Synthesis and
Characterization of Hyperbranched Polyfluorinated Polymers”, Macromolecules
1998, 31, 776-786.
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